Premise Health is Different on Purpose

Premise Health serves large organizations and their people with exceptional healthcare. The result? Better experiences, better health, and better value, all while helping organizations lower their healthcare costs. 

Premise's mission is to help people get, stay, and be well. Come join us and see for yourself why amazing health starts with amazing healthcare. For more information, visit www.jobs.premisehealth.com. 

As the AI Engineering Senior Principal, you will serve as the strategic leader and architect for Premise Health's AI engineering initiatives, responsible for defining and implementing enterprise-wide AI architecture, strategy, and best practices. This role combines deep technical expertise in artificial intelligence, information security, cloud architecture, and enterprise systems with strong leadership capabilities to build and guide the organization's AI transformation. The ideal candidate will have extensive experience in healthcare technology, information security architecture, AI/ML solutions, cloud-native application development, and agile methodologies. This position requires a visionary leader who can bridge the gap between business strategy and technical execution while ensuring security, compliance, scalability, and operational excellence across all AI initiatives.

This is a Full Time, remote AI Engineering Senior Principal role.

What You'll Do

• Define and lead the enterprise AI architecture strategy for Premise Health, establishing architectural principles, standards, patterns, and best practices for AI/ML solutions across the organization.
• Design and architect secure, scalable AI solutions leveraging Large Language Models (LLMs), Retrieval-Augmented Generation (RAG), AI agents, and other advanced AI technologies while ensuring alignment with business objectives.
• Establish and enforce information security architecture for all AI systems, including Identity and Access Management (IAM), computer-to-computer authentication mechanisms, API security, data protection, and compliance with healthcare regulations (HIPAA, HITECH).
• Lead the creation of reference architectures for AI-powered applications that serve as reusable templates and accelerate development across multiple teams and business units.
• Partner with business and IT leaders to make investment decisions that balance current operational demands with long-term strategic vision for AI capabilities and innovation.
• Architect cloud-native AI solutions on Azure, AWS, and other cloud platforms, establishing patterns for microservices, serverless computing, event-driven architectures, and containerization.
• Design and implement secure API gateway strategies for both public and private APIs, ensuring proper authentication, authorization, rate limiting, and monitoring across all AI services.
• Establish DevOps and CI/CD practices for AI/ML solutions, ensuring continuous delivery, automated testing, model versioning, and deployment pipelines for AI systems.
• Lead cross-functional collaboration efforts between data science, engineering, security, and operations teams to deliver integrated AI solutions that meet business requirements.
• Evaluate and recommend emerging AI technologies, frameworks, and platforms based on business value drivers, return on investment, and alignment with enterprise architecture standards.
• Develop and maintain technology roadmaps for AI capabilities, identifying opportunities for automation, process improvement, and innovation using artificial intelligence and machine learning.
• Architect healthcare-specific AI solutions with expertise in health data interchange standards (HL7, FHIR) and healthcare workflow automation using AI and RPA technologies.
• Establish governance frameworks for responsible AI, including ethical AI principles, bias detection and mitigation, model explainability, and compliance with regulatory requirements.
• Lead the architecture team for AI initiatives, including recruitment, development, mentoring, and performance management of architects and senior technical staff.
• Create and maintain comprehensive architectural documentation including solution architectures, technical specifications, integration patterns, security models, and decision records.
• Conduct architectural reviews and provide technical guidance to development teams working on AI-powered services, products, and platforms.
• Design multi-tenant SaaS architectures for AI applications that support multiple regions, ensure data isolation, and provide accurate cost allocation and billing.
• Establish architectural patterns for integrating AI capabilities into existing systems, including event sourcing, pub/sub messaging, claim check patterns, sidecar patterns, and gateway patterns.
• Lead proof-of-concept and pilot initiatives to validate new AI technologies and architectural approaches before enterprise-wide adoption.
• Collaborate with information security teams to ensure all AI solutions meet security requirements for authentication, authorization, encryption, audit logging, and threat protection.
• Develop communication strategies and materials to evangelize AI architecture principles and best practices across the organization at all levels from technical teams to executive leadership.
• Advise executive leadership on AI strategy, technology options, risks, costs versus benefits, system impacts, and implementation priorities.
• Drive migration strategies to transition legacy systems to modern AI-enabled cloud-native architectures with minimal disruption to business operations.
• Establish practices for resource allocation, cost optimization, and performance monitoring for cloud-based AI solutions.
• Champion agile ways of working and modern development practices across AI engineering teams, including iterative development, continuous improvement, and DevOps culture.
• Ensure AI solutions are architected for high availability, disaster recovery, scalability, performance, and operational excellence.

What You'll Bring

• Master's degree in Computer Science, Engineering, Information Systems, or related technical field required; or equivalent combination of education and experience.
• Advanced certifications in enterprise architecture frameworks (TOGAF, Zachman) strongly preferred.
• Cloud architecture certifications (Azure Solutions Architect Expert, AWS Certified Solutions Architect) strongly preferred.
• 15+ years of experience in information technology with at least 7 years in enterprise architecture, solutions architecture, or technical leadership roles required.
• 5+ years of experience in AI/ML architecture, including hands-on experience with Large Language Models, AI agents, RAG architectures, and AI application development required.
• 7+ years of experience in healthcare technology with deep understanding of health data standards (HL7, FHIR), healthcare workflows, and regulatory compliance (HIPAA, HITECH) required.
• Proven experience as Principal Architect, Principal Information Security Architect, or equivalent senior technical leadership role required.
• 5+ years of experience leading architecture teams and managing diverse technical teams required.
• Extensive experience architecting and implementing cloud-native applications on Azure and/or AWS, including migration strategies from on-premises to cloud-first organizations required.
• Strong background in information security architecture, including IAM solutions, authentication and authorization mechanisms (OAuth, SAML, OpenID Connect), API security, and security infrastructure required.

Work-life balance is at the foundation of how decisions are made and where Premise is headed. We can only help people get, stay, and be well if we do the same for ourselves. In addition to competitive pay, Premise offers full-time team members benefits including medical, dental, vision, life and disability insurance, a 401(k) program with company match, paid holidays and vacation time, a company-sponsored wellness program, EAP, access to virtual primary care and virtual behavioral health at no cost for team members and their dependents. Additional benefits can be viewed here: https://jobs.premisehealth.com/benefits.

Premise is an equal opportunity employer; we value inclusion and do not discriminate based on race, color, religion, creed, national origin or ancestry, ethnicity, sex (including pregnancy and related conditions), gender identity or expression, sexual orientation, age, physical or mental disability, genetic information, past, current or prospective service in the uniformed services, or any other characteristic protected under applicable federal, state, or local law.

Premise provides its reasonable and genuinely expected range of compensation for this job of $160,000.00 - $200,000.00 annually / per hour. A number of factors will influence the rate offered for this position, including your experience, qualifications, geographic location, and other factors. 

For individuals living in Washington or Colorado: Premise offers the following paid time off benefits. Employees will earn 0.0692 hours of paid time off per actual hours worked or based on standard schedule, per pay period, and will receive 10 paid holidays or an equivalent bank of hours aligned to schedule throughout the calendar year. Paid sick leave is satisfied by the paid time off accrual, detailed above. 

This posting is anticipated to close within 90 days of 02/25/2026. 

Should you have questions regarding this job posting, please contact askhr@premisehealth.com.